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KMID : 0361520080190060341
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Korean Journal of Psychopharmacology
2008 Volume.19 No. 6 p.341 ~ p.347
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Aberrant Response of Selective Serotonin Reuptake Inhibitor in Two Patients with High N100 Amplitude Slope
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Lee Seung-Hwan
Choo Jung-Sook
Park Young-Min
Kim Jin-Hwan
Lee Jae-Hyuk
Kim Sang-Rae
Bae Sung-Man
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Abstract
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Serotonin is one of the most important neurotransmitters involved in the pathophysiology of depressive illness. The assessment of alteration of cerebral serotonin has been still controversial but interesting topic to study. Recently, increasing evidence has accumulated that the N100 amplitude slope reflects cerebral serotonin activity and treatment response of selective serotonin reuptake inhibitors (SSRIs). We report on two patients who showed abrupt mood changes and side effects after taking SSRI antidepressants. In both patients, aberrantly high N100 amplitude slopes were observed. Our cases suggest that the N100 amplitude slope may be a reliable indicator for predicting manic conversion and side effects in the SSRI treatment of depressive patients. Controlled studies are necessary to confirm whether a high N100 amplitude slope is a useful indicator of SSRI supersensitivity
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